Effect of Cadherin-11 on the Proliferation, Migration, and ECM Synthesis of Chondrocyte

Nonsyndromic microtia is a kind of congenital ear malformation with unclear pathogenic genes. Cadherin-11 (CDH11, OB-cadherin) member the cadherin family, which has been demonstrated to play important roles in controlling morphogenesis and cell biological characteristics during multiple developmental processes. In present study, we found low expression CDH11 cartilage compared normal one for first time. For more comprehensive in-depth understanding development, performed both gain- loss-of-function experiments detect effect on chondrocytes. promoted chondrocyte proliferation by increasing S-phase numbers migration, tissue morphogenesis. Additionally, knockdown chondrocytes reduced quality engineered decreasing key transcription factors chondrogenesis, SOX9 expression, ECM production, including collagen type II (COL2A) elastin (ELN), control group. Furthermore, RNA-Seq showed that it was highly related HOX family genes, have reported be regulatory genes patterning craniofacial formation. This study identified as candidate gene supported potential role malformations.